Diethyl 2-oxo-2-phenylethylphosphonate

Diethyl 2-oxo-2-phenylethylphosphonate - Names and Identifiers

Name	Diethyl(2-oxo-2-phenylethyl)phosphonate
Synonyms	NSC 648426 AIDS139382 DIETHYL PHENACYLPHOSPHONATE Diethyl phenacyl phosphonate α-(Diethoxyphosphinyl)acetophenone DIETHYL(2-OXO-2-PHENYL)PHOSPHONATE diethyl (2-oxo-2-phenethyl)phosphonate Diethyl 2-oxo-2-phenylethylphosphonate Diethyl(2-oxo-2-phenylethyl)phosphonate DIETHYL (2-OXO-2-PHENYLETHYL)PHOSPHONATE Diethyl (2-oxo-2-phenylethyl)phosphonate 2-Phenyl-2-oxoethylphosphonic acid diethyl ester
CAS	3453-00-7
InChI	InChI=1/C12H17O4P/c1-3-15-17(14,16-4-2)10-12(13)11-8-6-5-7-9-11/h5-9H,3-4,10H2,1-2H3

Diethyl 2-oxo-2-phenylethylphosphonate - Physico-chemical Properties

Molecular Formula	C12H17O4P
Molar Mass	256.23
Density	1.179 g/mL at 25 °C (lit.)
Boling Point	192-193 °C/11 mmHg (lit.)
Flash Point	>230°F
Vapor Presure	9.01E-06mmHg at 25°C
Appearance	clear liquid
Color	White to Yellow to Green
Storage Condition	Room Temprature
Refractive Index	n20/D 1.513(lit.)

Diethyl 2-oxo-2-phenylethylphosphonate - Risk and Safety

WGK Germany

Diethyl 2-oxo-2-phenylethylphosphonate - Introduction

Diethyl(2-oxo-2-phenylethyl)phosphonate is an organophosphorus compound with the formula C12H15O4P. Its nature is as follows:

1. Appearance: colorless to yellowish liquid;
2. melting point:-16 ℃;
3. Boiling point: 145 ℃;
4. density: 1.177g/cm³;
5. Solubility: Soluble in ethanol, ether and other organic solvents.

Diethyl(2-oxo-2-phenylethyl)phosphonate has a wide range of applications, including:

1. organic synthesis reagent: it can be used in organic synthesis reaction, such as as alcohol, ether, ketone synthesis intermediates;
2. pharmaceutical chemistry: as an intermediate in the synthesis of anticancer drugs;
3. pesticide chemistry: used in pesticide synthesis of pesticides, fungicides and other synthetic intermediates.

Diethyl(2-oxo-2-phenylethyl)phosphonate is usually prepared by the following steps:

1. reacting acetophenone with phosphorus triiodide to form 2-iodo-2-phenylethylnitrile;
2. 2-iodo-2-phenylethylnitrile is reacted with diethoxyphosphonic acid to obtain the target product.

For the safety of chemicals, you need to pay attention to the following:

1. It is a flammable liquid and needs to be stored in a cool and well-ventilated place;
2. contact or inhalation may cause irritation and corrosive harmful to the skin, eyes and respiratory system;
3. in the use of the process should wear appropriate protective equipment, to avoid direct contact.

When using and handling this chemical, please follow the relevant safety procedures and refer to the material's safety data form.

Last Update：2024-04-09 21:21:28